Molecular Formula | C29H37N3O6 |
Molar Mass | 523.62 |
Density | 1.23±0.1 g/cm3(Predicted) |
Boling Point | 784.1±60.0 °C(Predicted) |
Water Solubility | Soluble in water. |
Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
Appearance | Solid |
Color | Yellow to Dark Yellow Sticky |
pKa | 15.14±0.46(Predicted) |
Storage Condition | -20°C Freezer, Under inert atmosphere |
In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
biological activity | DBCO-NHCO-PEG4-amine is a PROTAC Bridge belonging to the PEG class. DBCO-NHCO-PEG4-amine is a cleavable ADC linker that can be used to link MMAE (HY-15162) and antibodies (e. G., DBCO-VCpAB − MMAE and DBCO-TRX − MMAE, EC50 for SKBR3 cells were 280 nM and 22 nM, respectively). |