3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]propanamide
DBCO-PEG4-NH2
CAS: 1255942-08-5
Molecular Formula: C29H37N3O6
3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]propanamide - Names and Identifiers
3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]propanamide - Physico-chemical Properties
| Molecular Formula | C29H37N3O6 |
| Molar Mass | 523.62 |
| Density | 1.23±0.1 g/cm3(Predicted) |
| Boling Point | 784.1±60.0 °C(Predicted) |
| Water Solubility | Soluble in water. |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Yellow to Dark Yellow Sticky |
| pKa | 15.14±0.46(Predicted) |
| Storage Condition | -20°C Freezer, Under inert atmosphere |
| In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]propanamide - Reference Information
| biological activity | DBCO-NHCO-PEG4-amine is a PROTAC Bridge belonging to the PEG class. DBCO-NHCO-PEG4-amine is a cleavable ADC linker that can be used to link MMAE (HY-15162) and antibodies (e. G., DBCO-VCpAB − MMAE and DBCO-TRX − MMAE, EC50 for SKBR3 cells were 280 nM and 22 nM, respectively). |
Last Update：2024-04-09 02:00:10
![3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]propanamide](http://res.chembk.com/assets/str/2d/1/12/1255942-08-5.png)
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CAS: 1255942-08-5
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CAS: 1255942-08-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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